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  55. France drafts law to extend IVF to lesbians, single women
  56. French air-board inventor flies across the English Channel
  57. Images show Lightsail 2 spacecraft’s solar sail has deployed
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  63. Tom Brady’s rumored fashion line could have a supermodel adviser in Gisele
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  77. JPMorgan CEO Jamie Dimon knocks Facebook’s Libra, ‘I wouldn’t spend too much time on it’
  78. How T-Mobile, AT&T, Verizon and Sprint fight robocalls on their network
  79. LVMH’s Bernard Arnault dethrones Bill Gates as second richest person in the world
  80. Amazon Prime Day 2019, by the numbers: Sales increased 72%
  81. EU probes Amazon over use of retailer info to gain edge
  82. IMF chief Christine Lagarde to resign on Tuesday
  83. FaceApp goes viral with old-age filter, but spurs privacy concerns with Russian roots
  84. Johnson & Johnson responds to opioid case, promises to defend against baby powder suits
  85. Brain-controlled robot hand with sense of touch helps Medal of Honor recipient
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  88. Telescope viewing suspended as protesters block Hawaii road
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  95. US deficit could top $1T in 2019
  96. DeVos: Efforts to boycott Israel are a ‘pernicious threat’
  97. R. Kelly denied bail in sex trafficking case
  98. JPMorgan’s Jamie Dimon: Economy ‘not that bad’ as bank preps for 3 rate cuts in 2019
  99. Amazon Prime Day sales: Early estimate shows gain from last year
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  109. Wells Fargo’s 2Q earnings beat expectations
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  122. The best-selling Instant Pot is at its lowest price ever
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  126. Skopje zoo’s chimp returns after recovering from depression
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  134. ‘No Tech for ICE’: Protesters demand Amazon cut ties with federal immigration enforcement
  135. White House yanks drug ‘rebate’ plan to ease costs for some
  136. Ashton Kutcher, Mila Kunis singing children’s song ‘La Vaca Lola’ is an embarrassing parent gem
  137. Does it matter which body lotion I use?
  138. Fed Chairman Powell: Facebook’s Libra raises ‘many serious concerns’
  139. The Fashion Transparency Index: 2019 report ranks world’s biggest brands
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  142. Air bag defect probe expands to include 12.3 million more vehicles
  143. ConocoPhillips sells off UK North Sea assets for £2bn
  144. Boeing tests 737 Max software updates, says it’s making ‘progress’ on certification
  145. ‘You won’t find this on Capri’: Italy’s Tremiti Islands ‘You won’t find this on Capri’: Italy’s Tremiti Islands
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  147. Tesla wants to cut size of board from 11 directors to 7
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  154. How Fannie Mae, Freddie Mac dodged a $600,000 cap on CEO pay
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  161. Taxpayer spending on U.S. disaster fund explodes amid climate change, population trends
  162. See royal baby Prince Louis of Cambridge on his first birthday
  163. Michelle Branch and Patrick Carney of The Black Keys are married! See the photo
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  170. “Alexa, play some free songs for me”
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  173. Craftsmen built Notre Dame eight centuries ago. Now it may be up to robots to save it.
  174. Netflix warns price rises to hit subscriber growth
  175. Wendy Williams to leave sober house following divorce filing: ‘It’ll be Wendy on her own’
  176. For summer road trips, a new app turns insect splats into a detective game
  177. Alexa, play free music for me? Amazon may challenge Spotify and Pandora, report says
  178. Instagram couple responds to ‘stupid’ infinity pool photo controversy
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  180. Advocates hoped census would find diversity in agriculture. It found old white people.
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  189. Nunes to send 8 criminal referrals to AG Barr this week
  190. NASA is scrambling to meet the White House mandate to return astronauts to the moon by 2024
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  206. Fueled by climate change, extreme weather disasters hit 62 million people in 2018, U.N. says
  207. Chick-fil-A pulled from Buffalo airport after company’s alleged ‘anti-LGBTQ rhetoric’ sparks backlash
  208. Google suspended from LGBTQ equality index after failing to remove controversial app
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  211. Justices reject new colleague’s arguments in fraud case
  212. Lyft valued at $24bn ahead of share market debut
  213. Boeing’s Max jet lobbying part of Transportation Department probe
  214. Trump says Google committed to US military, not China
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  217. Airbus secures multi-billion dollar jet order from China
  218. ‘The Voice’ Battle Rounds: This Adele duet will give you goosebumps
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  222. Nintendo may soon add a cheaper and a more powerful Switch to its lineup, report says
  223. American Airlines passenger urinated on fellow traveler’s luggage, police say
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  225. With its ties in Washington, Boeing has taken over more and more of the FAA’s job
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  227. Elizabeth Warren calls for release of taxpayer-funded Mueller report
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  237. Facebook says it left ‘hundreds of millions’ of users’ passwords stored in plain text
  238. Thermo Fisher to buy Brammer Bio for $1.7B
  239. UPS eyes in-home health services with US vaccine project
  240. Chick-fil-A banned from San Antonio airport over alleged ‘legacy of anti-LGBTQ behavior’
  241. Ex-Autonomy boss Mike Lynch denies new US charges
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  244. Ask Amy: Reader offers a welcome update to past advice
  245. Asia stocks: Markets sink as global growth jitters spread
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  247. Lisa Wardell walked into a meeting with 14 white, male bankers — and she ran the room
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  270. Bill Gates just joined Jeff Bezos in ultra-exclusive $100 billion club
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  277. World’s most expensive city in 2019 is a 3-way tie
  278. Brexit: Port of Dover warns of travel disruption risk
  279. Volvo says in-car cameras will monitor drivers and take action to prevent distracted or impaired driving
  280. Can Apple compete with Netflix on streaming?
  281. Cities where Americans have the most cash left over after paying their mortgages
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  301. Peloton takes steps toward IPO
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  310. Talk is not cheap when it comes to love and money
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  312. Ask Amy: Boyfriend disappears into dark web
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  322. YouTube is changing its algorithms to stop recommending conspiracies
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  328. Blue Origin shoots NASA experiments into space in test
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Claudia Kieffer remembers the 1st time she experienced the medication she details as getting “saved our life”. 8 years ago, Kieffer, who acquired suffered from treatment-resistant depression for many years, was given ketamine as a regimen anaesthetic, included in a post-mastectomy breast renovation procedure.

Yet as well as relieving the pain, Kieffer noticed a good instantaneous modify in the girl state of mind.

“My head abruptly felt dissimilar to any earlier time in playing, ” the girl says. “I wasn’t higher. It was not like My spouse and i smoked the joint or even had morphine. It was just like a spring air flow had taken through me and just washed all the detritus that got built up more than years and years. So when you’ve experienced depression so long as I had, seems like you are drowning. Then when something arrives that makes you are feeling so completely different and healthful, you want to understand what that medication is. ”

At the time, Kieffer had attempted almost every depression-related treatment offered, without achievement. “I’d got three anxious breakdowns plus been hospitalised three times, ” she recalls. “I’d experienced 13 models of electric-shock therapy plus it didn’t assist. When I is at my twenties and 30s, I would self-medicate, just because that is what you do once you don’t understand what else to carry out. I was thinking of taking my entire life every single day. I would like to get to sleep and not get up. ”

Yet unbeknown with her at the time, an increasing number of clinical studies was already checking out the potential advantages of ketamine infusions as a therapy for major depression. Two years right after her procedure, Kieffer enrollment on one this kind of study, operate by the ALL OF US National Institutes for Wellness.

“The scientists were amazed at exactly how well this worked for me personally, ” the lady says. “There were some other patients to get whom the consequences lasted to get maybe a day time, but for myself it was fourteen days. So from then on I started going to a therapy centre once per month for an infusion and now that is how I reside. If I proceed too long with no it, matters can quickly slide back. Yet I have wish now. ”

Kieffer can be far from solely. There are a large number of similar tales, both in the united states and the UNITED KINGDOM, where psychiatrists sometimes recommend ketamine off-label as a last-ditch treatment for that estimated 12-20% of despression symptoms patients just for whom almost every other medication is unsucssesful. For whilst ketamine is better known within modern lifestyle as whether powerful anaesthetic – whenever applied within large dosages – or even “Special K”, the golf club drug along with mind-bending psychedelic effects, the new make use of is quickly gaining energy.

In the US, fda recently produced the milestone decision in order to officially permit a ketamine-related drug known as Spravato being a medication intended for depression. Because the first story regulatory-approved therapy for the situation in more compared to 30 years, it is about with huge expectations. Yet experts alert that it is not necessarily the “miracle cure” – it may come with side effects and there is nothing known concerning the risks associated with using it long-term.

The main reason why ketamine has captivated so much interest is the speedy effect it may have upon patients that have exhausted other treatment options. Whilst traditional medicine take a few weeks before sufferers feel any kind of relief, ketamine works within hours as well as the benefits of just one dose may last for up to per week. Because of the quickness with which functions, doctors in america will often give ketamine infusions to er patients who may have attempted to eliminate themselves.

Among the complexities associated with depression is certainly how varied it is. There may be a range of signs and symptoms and, as opposed to other medicine, ketamine seems to have wide-ranging benefits throughout many of them. Correctly shown results in individuals with stressed bipolar depressive disorders, PTSD, anhedonia or lack of pleasure plus suicidal thoughts. All of this led Jones Insel, the previous director from the US Nationwide Institutes associated with Mental Wellness, to describe ketamine as possibly “the most significant breakthrough within antidepressant therapy in decades”.

“What’s especially interesting regarding ketamine is it has several effects all through different human brain biologies, ” says Doctor Carlos Zarate, head associated with experimental therapeutics and pathophysiology at the ALL OF US National Start of Psychological Health, who have conducted the very first clinical demo of ketamine for despression symptoms in 06\. “This helps it be much more distinctive than various other treatments. Most of the symptom domain names seen in despression symptoms, but not all of the, seem to react to it. ”

The reason researchers were powered to try ketamine in the first place is due to long-standing ideas that it prevents receptors within the brain that will interact with the particular neurotransmitter glutamate, a key mind chemical lengthy implicated within mental health problems. But they continue to be trying to tease apart precisely how it works.

Intriguingly, ketamine’s antidepressant effects seem to take place right after it simply leaves the body, that is something researchers don’t realize. One concept is that it activates the brain in order to regrow contacts between tissues that are involved with mood, yet no one actually knows for certain.

At the same time, ketamine does not consistently work. There has been other research where couple of patients gained, while the price of infusions on private treatment centers in the US – estimated through $350 in order to nearly $1, 000 – has demonstrated prohibitive for a lot of patients. Problems have also been frequently raised regarding its recognized side-effect user profile, which can consist of hallucinations plus out-of-body encounters following therapy, as well as variances in stress.

Part of the cause that Spravato has been created, and now given the green light by the FOOD AND DRUG ADMINISTRATION, is to attempt to make ketamine more available. The $900 cost for each treatment is going to be covered partially by medical health insurance and its becoming administered being a nasal aerosol reduces the chance of side-effects in contrast to an infusion. The only tug at is that it isn’t really technically ketamine.

Ketamine consists of two mirror-image molecules, therefore in order to transform it into a possible cash cow, pharma business Janssen trademarked the remaining one – esketamine – and converted it in to a drug plus named this Spravato. The thing is that there is not a large amount of proof that it is as efficient as ketamine infusions. To begin with, Spravato provides only already been studied within four pretty small stage III tests, three which lasted just four weeks. The outcomes were absolutely mixed and several scientists possess pointed out that the particular FDA tranquil its typical rules meant for accepting medications, in order to allow it to through.

“I didn’t discover the evidence convincing, ” states Julie Zito, professor associated with pharmacy plus psychiatry on the University associated with Maryland. “They evaluated the particular efficacy making use of symptom rating change plus there was just a three- in order to four-point enhancement on a 60-point scale, that you’ve to say is extremely modest. Which is what the event hangs upon. And the FOOD AND DRUG ADMINISTRATION created this particular new revolutionary study class, which means they will only necessary one randomised, double-blind placebo-controlled trial, not really two, that is usually the particular criterion to get a new medication. ”

Researchers in favour of the particular drug believe there should be several leniency, provided the lack of current treatments just for patients along with severe depressive disorders, but Zito says the particular clinical studies also elevated some severe safety problems.

“I’m worried about the hallucinations that were notable in some people, ” the lady says. “You’re going to have got people arriving at a center, receiving a dosage, waiting for 2 hours… and don’t understand what’s likely to happen there after. There were 3 suicides that occurred within the Spravato-exposed team, and a 4th death that will, for me, has been suspicious: the motorcycle incident in which a guy drove right into a tree immediately after the dosing. The manufacturer promises that all these events are usually unrelated to make use of of the medication, but nothing like this happened within the placebo team. ”

Along with depression as being a chronic problem, there is also the chance that patients might need to continue therapy over a period of yrs or even years. Little is well known about the long lasting effects to the body associated with either Spravato or ketamine infusions.

Yet as Zarate points out, provided the lack of choices for patients, the advantages that could originate from treatment could very well outweigh any kind of potential dangers.

“Depression causes intellectual problems, center and lung problems, bone tissue problems, along with the risk associated with death through suicide, then when it comes to dealing with patients along with ketamine intended for long periods of time, it is a risk-benefit judgment, ” he says. “To leave your body in that on-going state is just not good possibly. But nobody’s saying we are not ongoing to study ketamine. If you will find complications plus side-effects that individuals don’t learn about, we will see them. ”

This kind of is the expectations around Spravato that experts have already expected the medication will produce more than $600m in product sales by 2022, despite the family member paucity associated with studies showing its advantages.

Its results may also be wide-reaching, potentially introducing the way for the new course of rapid-acting antidepressants. Recently, researchers have got begun in order to re-examine some other psychoactive elements which were initial touted since potential medicine in the 1950s, for example psilocybin, the particular active ingredient within magic mushrooms, and ECSTASY. Some scientific trials have previously suggested it might have helpful effects upon patients.

Yet there is a darkish side towards the rise associated with ketamine – and, within future, possibly psilocybin – about which usually scientists have got long been worried. Such could be the hype round the possible advantages of these remedies that the possibility of their mistreatment among sufferers looking to self-medicate is very higher. Dr Rupert McShane, who else leads the particular UK’s just ketamine therapy centre, states there’s the need to setup a sign-up that screens exactly what individuals are taking, to get accurate details about long-term causes harm to within the inhabitants.

“It can be done that people find yourself treating on their own with ketamine obtained unlawfully, ” McShane says. “One of the items that happens along with ketamine can be [that]because it enables you to feel better therefore quickly, once you relapse you would like to take it once again. And when the particular dosage plus frequency obtain too high, that is when it gets toxic. Therefore it’s necessary to track remedies, because among the issues within the opiate dependancy epidemic was your difficulty of having any information that demonstrated the degree of the issue. ”

Zito also concerns that the buzz around ketamine could lead to individuals seeking therapy when they are not sufficiently sick enough in order to require it. “There’s been an enormous expansion about what constitutes despression symptoms, ” the girl says. “There are low-moderate depressives that are going through the divorce or battling a new job… what they may really need is certainly counselling. However in the US, all of us love our own pills plus simple methods to very complicated problems. ”

Kieffer’s major hope would be that the FDA’s acceptance of Spravato will slow up the stigma plus negative organizations around ketamine treatment.

“People kept talking about it since the club medication and I want it whenever we could simply erase that will from the language and state the ‘depression drug, ’” she states. “It’s annoying as a affected person to have in order to constantly protect myself to take it, mainly because people furthermore use it to obtain high. Dont really know everything about that. Many I know is the fact that it’s provided me my entire life back. ”

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